Santee Cooper is on the south side of Lake Marion, just east of I-95 off exit 98.

The golf course is a solid parkland layout along fairways defined by pine trees over rolling terrain. There are numerous sand traps along the fairways and around the greens, numerous slight and dramatic doglegs, and 1/3 of the holes with water hazards in play, including an 18th hole overlooking the Lake. It plays to 6,589 yards from the tips, 71.1/124, course/slope ratings with three shorter tees, designed by George Cobb.